AKT1 and gastric cancer: In this study, we found that while IL-4 promoted the M2 polarization of macrophages in vitro, it also caused metabolic reprogramming of macrophages in the gastric cancer microenvironment by up-regulating the PI3K/AKT/mTOR signaling pathway: oxidative phosphorylation was inhibited, glycolysis was enhanced, the production of lactic acid increased.