TMEM165 and autism spectrum disorder: On the other hand, there seems to be a negative correlation between Tmem165 and autistic spectrum disorder (ASD): serum extracellular vesicles (EVs) obtained from ASD children aged 3.5 years were found to express TMEM165 mRNA in significantly lower levels compared to controls (99); several other genes involved in the glycosylation process were also downregulated in ASD (99).