ABO and thrombophilia: In turn, aberrant glycosylation has been shown to promote both epithelial to mesenchymal transition, an early step in malignant transformation,65,66and hypercoagulability.67, 68, 69, 70 Mechanistic studies are required to dissect its role in the inter-relationship between cancer and thrombosis, and thus to determine whether ABO's pleiotropy is truly vertical (as our work suggests) rather than horizontal.