In addition, individual gene MR (only using IVs within 1 Mb from the gene body) analyses using HNF4G (OR = 1.09, P = 0.083) and PDX1 (OR = 1.10, P = 0.015) also suggested a causal effect of PDAC on T2D. This evidence concerns the gene PDX1 and type 2 diabetes mellitus.