Tobacco smoking is the leading risk factor for lung cancer.3 Unfortunately, while smoking cessation programs are recommended, they are not standardized in clinical care.3 Additionally, popular alternatives such as cannabis smoking and vaping, especially among youth, present additional less defined lung cancer risks.4,5 Air pollution, family history, DNA repair capabilities, and germline mutations also contribute to lung cancer.6,7 Inflammatory responses triggered by fine particulate matter (PM2.5) are associated with EGFR- and KRAS-driven lung cancers.7 This evidence concerns the gene EGFR and lung cancer.