This unveiled that the combined approach of FST and TIMP-2*IGFBP-7 after two hours still remained an independent risk predictor for RRT within the subsequent seven days in SA-AKI, with an odds ratio of 12.19 (95%-CI: 2.44 to 81.16, p < 0.01), as illustrated in Table 4. This evidence concerns the gene TIMP2 and acute kidney injury.