On the tissue injury side, on the other hand, urinary biomarkers such as the Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) and Insulin-like Growth Factor-Binding Protein-7 (IGFBP-7), as measured in combination by the commercially available NEPHROCHECK® test, have shown substantial efficacy in early discerning the trajectory of AKI [16–19]. The gene discussed is TIMP2; the disease is acute kidney injury.