Strikingly, a recent report from Nagpal and colleagues revealed that, rather than apoptosis as induced by other TKIs, such as lapatinib, neratinib promoted non-apoptotic cell death called ferroptosis in both human (SKBR3) and mouse (TBCP1) HER2-positive breast cancer cell lines [14]. This evidence concerns the gene ERBB2 and breast carcinoma.