Further investigations in rat colon tissues and the integration of published bulk RNA-sequencing analyses revealed that ferritinophagy-mediated ferroptosis may be the underlying feature of not only colon injury, especially in the surface lining colonocytes, but also cell death in the HER2-positive TBCP-1 breast cancer cell line and HER1-mutant TS895 glioblastoma xenografts. The gene discussed is ERBB2; the disease is breast cancer.