Mechanistically, following the release of interferon gamma (IFNγ) from active CD8+ T cells and interaction with cognate receptors on melanoma and colon cancer cells, the downstream signalling of IFNγ robustly induced ferroptotic cell death by stimulating the uptake of arachidonic acid and upregulation of ACSL4 while suppressing the expression of SLC7A11, which encodes for system Xc− essential for cysteine uptake [56, 57]. The gene discussed is ACSL4; the disease is melanoma.