Together with a significant increase in iron uptake previously observed in neratinib-treated TBCP-1 cells [14], our bulk RNA-sequencing analyses collectively suggested that HER1-mutant TS895 and HER2-positive TBCP1 cancer cells potentially underwent ferroptotic cell death, which appeared to arise from perturbed iron homeostasis through ferritinophagy, following neratinib treatment. The gene discussed is EGFR; the disease is cancer.