SIRT2 and pro-inflammatory cytokines were examined and serum SIRT2 expression was found to be elevated in acute ischemic stroke (AIS) patients compared to controls, further analyses demonstrated that SIRT2 expression data could distinguish AIS patients from controls (AUC = 0.890, 78.7% sensitivity and 91.5% specificity). The gene discussed is SIRT2; the disease is androgen insensitivity syndrome.