IGF1 and Impaired glucose tolerance: This elevation suggested systemic atherosclerosis linked to impaired glucose tolerance.S1–3 On the other hand, serum expression of TNFRSF1A, CXCL4, MIP‐1 γ, MMP‐3, VEGFR2, IGF‐1, HGFR, OPN, and OPG was significantly lower in db/db mice.