This elevation suggested systemic atherosclerosis linked to impaired glucose tolerance.S1–3 On the other hand, serum expression of TNFRSF1A, CXCL4, MIP‐1 γ, MMP‐3, VEGFR2, IGF‐1, HGFR, OPN, and OPG was significantly lower in db/db mice. This evidence concerns the gene KDR and Impaired glucose tolerance.