This elevation suggested systemic atherosclerosis linked to impaired glucose tolerance.S1–3 On the other hand, serum expression of TNFRSF1A, CXCL4, MIP‐1 γ, MMP‐3, VEGFR2, IGF‐1, HGFR, OPN, and OPG was significantly lower in db/db mice. The gene discussed is SPP1; the disease is Impaired glucose tolerance.