Interestingly, tumour‐induced alterations in the expression of Atrogin1, MuRF1, Pik3r1, Pdk4, Myh4, Myh2 and Myh1 were attenuated in EDA2R‐deficient muscles, implying that the EDA2R pathway contributes to the reprogramming of muscle gene expression during cancer cachexia (Figure4D). This evidence concerns the gene PIK3R1 and cancer.