In this sense, it has been shown that the hypercaloric high‐sucrose model induces insulin resistance (IR) (determined by HOMA index, glucose and insulin tolerances, glucose uptake by peripheral tissues and fasting insulin levels), hyperlipidemia, adiposity, obesity and impaired lipidic and glycolytic metabolisms (Rodríguez‐Correa et al., 2020). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.