TGFB1 and neoplasm: On the other hand, RT attracts immunosuppressive cells such as M2 tumor-associated macrophages, myeloid-derived suppressor cells, regulatory T cells, and N2 neutrophils, which have immunosuppressive effects in the tumor microenvironment by releasing immunosuppressive cytokines (TGF-β, IL-10) and chemokines [37].