In each of the six NSCLC cell lines, we measured the expression levels of catabolic enzymes (PDE isoforms 8a, 8b, 5a, 9a, and 10a) and anabolic enzymes (adenylate cyclase, ADCY, and guanylate cyclase, GUCY) involved in cyclic nucleotide metabolism (Figure 1A,B). The gene discussed is ALDH7A1; the disease is non-small cell lung carcinoma.