ADCY1 and non-small cell lung carcinoma: In each of the six NSCLC cell lines, we measured the expression levels of catabolic enzymes (PDE isoforms 8a, 8b, 5a, 9a, and 10a) and anabolic enzymes (adenylate cyclase, ADCY, and guanylate cyclase, GUCY) involved in cyclic nucleotide metabolism (Figure 1A,B).