RAC1 and neoplasm: For example, the RAC1 GEFs dedicator for cytokinesis 4 (DOCK4) and DOCK7 play a role in CRC, where DOCK4 could represent a new CRC biomarker for immune infiltration, and DOCK7 promotes CRC metastasis through secretion in macrophage-derived extracellular vesicles that activate RAC1 in CRC tumor cells [82,83].