EGFR and colorectal carcinoma: Studies have shown that there is a correlation between the epithelial marker E-cadherin and sensitivity to EGFR inhibition, where cells expressing E-cadherin are more sensitive to EGFR inhibition; on the other hand, CRC cell lines expressing mesenchymal markers such as Zeb1, vimentin, and Snail are insensitive to EGFR inhibitors [155].