TP53 and cancer: Among the selected 22 miRNAs, seven miRNAs, that is miR-196b-5p, miR-182-5p, miR-200c-3p, miR-429, miRs-425-5p, 200b-5p and miR-9 were considered for further evaluation, on the basis of high number of reads in NGS analysis and common prevalence in at least four top KEGG categories (pathways in cancer, proteoglycan in cancer, the p53 signaling pathway and CRC category).