GRM5 and major depressive disorder: We found that three patients with HL were diagnosed with conditions, classified as paraneoplastic by their treating physicians: one girl presented with a clinical depression 6 months prior to HL diagnosis, one boy developed immune thrombocytopenia (ITP) 11 months prior to the tumor diagnosis and the third child was the index patient with mGluR5 antibody encephalitis (Ophelia syndrome).