In accordance, the protein expression of total and activated phospho-protein kinase C (PKC) delta, a primary regulator of STAT3 phosphorylation, was strongly reduced in BT-549 cells upon LDHC silencing, whereas the total PKCD, but not phospho-PKCD, expression was upregulated in HCC-1954 cells. The gene discussed is STAT3; the disease is hepatocellular carcinoma.