Comparative pathway analysis identified the GP6, STAT3 and G protein-coupled receptor signaling pathways to be the top three most significantly dysregulated pathways in both basal-like breast cancer cell lines, MDA-MB-468 and BT-549, but not in the Her2-enriched HCC-1954 cell line (Figure 2D—left). The gene discussed is STAT3; the disease is breast carcinoma.