CTLA4 and hepatocellular carcinoma: In October 2022, the Food and Drug Administration (FDA) has granted approval for the combination of the anti-PD-L1 antibody durvalumab with a single “priming” dose of the anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) antibody tremelimumab (STRIDE regimen) for first-line treatment of advanced HCC due to the positive results in the phase 3 trial [6].