AKR1B10 is a member of the aldo–keto reductase (AKR) superfamily that was identified as a novel protein correlated to the carcinogenesis of hepatocellular carcinoma (HCC), albeit the fact that the primary role of AKR1B10 is protecting gastrointestinal cells against carbonyl damage [17,18]. Here, AKR1B10 is linked to hepatocellular carcinoma.