In hepatocellular carcinoma (HCC), the subcellular redistribution is lost due to the lack of p53, leading to lipid peroxidation via plasma membrane (PM) DPP4 interactions with NADPH oxidase 1 (NOX1) (an interaction that can be blocked by DPP4i [26]), ultimately resulting in ferroptosis, a protective process in cancer patients. The gene discussed is TP53; the disease is hepatocellular carcinoma.