CDKN2A and gastroesophageal reflux disease: p16 expression in both nuclear and cytoplasmic expression (4+) and nuclear or cytoplasmic reactions (3+) was significantly associated with the degree of dysplasia (Table 1 and Figure 2): 10.7% (9/84) in BE, 23.1% (15/65) in BE-IND, 12.5% (1/8) in GERD, 64.4% (38/59) in LGD, 71.4% (15/21) in HGD, and 83.3% (10/12) in EAC.