MCM2 and Barrett esophagus: A strong positive MCM2 nuclear reaction (4+) was detected as 80.0% (44/51) in LGD, 100% (11/11) in HGD, 90.1% (10/11) in EAC, 7.4% (4/54) in BE, and 15.9% (7/44) in BE-IND, indicating that the overexpression of MCM2 is a differentiating marker for LGD, HGD, and EAC from BE and BE-IND (Table 2).