For chromosomal alterations, fluorescent in situ hybridization (FISH)—utilizing four fluorescently labeled locus-specific probe sets targeting 8q24 (MYC), 9p21 (CDKN2A; alias p16), 17g12 (ERBB2; alias Her-2/neu), and 20q13 (ZNF217)—was able to differentiate HGD and EAC from other BE-associated dysplasia with a sensitivity of 80% and a specificity of 88% [64,65,66,67,68]. The gene discussed is CDKN2A; the disease is Barrett esophagus.