A loss of p16 staining was observed as follows: 11.9% (7/59) in LGD, 14.3% (3/21) in HGD, 8.3% (1/12) in EAC (Figure 3B,F), 1.5% (1/65) in BE-IND, and 0% in BE. The gene discussed is CDKN2A; the disease is Barrett esophagus.