Aberrant beta-catenin staining with the increased expression of nuclear and cytoplasmic reaction (4+) occurred exclusively in LGD, HGD, and EAC (Figure 4G): 42.2% (14/33) in LGD, 50.0% (10/20) in HGD, 66.6% (2/3) in EAC, 4.5% (1/22) in BE-IND, and 0% in BE (Table 1). This evidence concerns the gene CTNNB1 and Barrett esophagus.