A weakly positive cyclin D1 nuclear reaction (1–2+) in a few cells was observed as follows: 40.8% (20/49) in BE, 17.9% (7/39) in BE-ITD, 4.7 (2/43) in LGD, and 0% in HGD and EAC. This evidence concerns the gene CCND1 and Barrett esophagus.