The authors defined the following five factors associated with poorer long-term survival: a node-positive primary tumour; a disease-free interval from primary to metastasis diagnosis of <12 months; a number of tumours > 1; a largest hepatic tumour diametre of >5 cm; and carcinoembryonic antigen (CEA) > 200 ng/mL. Here, CEACAM5 is linked to neoplasm.