KRAS and neoplasm: Interestingly, Margonis et al. showed no difference in long-term outcomes between patients with R0 and R1 resection who had KRAS mutations, but for those with wtKRAS tumours, an R1 resection was associated with a worse 5-year OS (HR 2.16, 95% CI 1.42–3.30, p < 0.001) [183].