Analysis of the mechanisms by which SMAD7 regulates CRC cell behavior revealed that SMAD7 binds the promoter of STAT3, and the AS-induced knockdown of SMAD7 reduces STAT3 mRNA and protein expression in CRC cells, suggesting a role for SMAD7 in the control of STAT3-dependent cancer cell behavior [23]. This evidence concerns the gene SMAD7 and colorectal carcinoma.