TP53 and cancer: Although this analysis did not reach statistical significance, TP53 carriers had the worst EFS (survival frequency: 0.364; 95% CI, 0.132–1; p = 0.38), compared to carriers in other cancer-predisposing genes (survival frequency: 0.667; 95% CI, 0.402–1, p = 0.38) (Supplementary Figure S1).