Adverse prognostic factors include metastatic disease at presentation, axial or proximal extremity tumour site, large tumour volume, older age [3], and blood-borne markers such as elevated serum alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and C-reactive protein (CRP) [3], with 5-year relative survival rates significantly higher for patients aged < 40 years compared to older patients > 40 years (25%) [4,5,6]. This evidence concerns the gene CRP and neoplasm.