CD274 and neoplasm: The heterogeneity of the study designs and evaluation methods, as seen in the research by Goh et al., 2023 [101], indicates that the responses are highly variable and influenced by individual tumor characteristics, such as PD-L1 expression (also known as the tumor proportion score; TPS), the tumor mutational burden (TMB), tumor-infiltrating lymphocytes (TIL), the host’s immune system, and molecular signatures [124].