At the endpoint, we examined the tumors by micro-CT and measured tumor FDG uptake by PET in vehicle- and TAM-treated groups and found markedly reduced FDG uptake in the mammary tumors in TAM-treated mice relative to the vehicle-treated group (Figure 4C) as has also been described as a result of PFKFB3 inhibition and heterozygous genomic deletion of Pfkfb3 [10,31]. The gene discussed is PFKFB3; the disease is neoplasm.