A critical role for PFKFB3-driven glycolysis in regulating tumor growth was confirmed by our examination of a constitutive knockout mouse model of the Pfkfb3 gene where we found that PFKFB3 was required for oncogene-driven anchorage-independent growth in vitro and xenograft growth in vivo [10,22]. The gene discussed is PFKFB3; the disease is neoplasm.