PFKFB3 and neoplasm: In order to evaluate the effects of PFKFB3 loss on tumor initiation and early tumor development, we crossed Cre/Pfkfb3fl/fl mice with K-rasLA1 mice and treated K-rasLA1/Cre/Pfkfb3fl/fl mice with vehicle ± TAM at 6 weeks of age for 5 days.