Several factors and stimuli, including hypoxia-inducible factor-1α [11,12], estrogen [13], progestins [14], growth factors [15,16], and proinflammatory molecules [17], have been demonstrated to actively promote the expression of the PFKFB3 enzyme and strongly indicate a prominent role for this enzyme in regulating glycolysis and proliferation in diverse processes, including inflammation, host defense, and cancer. This evidence concerns the gene PFKFB3 and cancer.