Notably, numerous studies have reported the expression of CXCR4 in tumor cells in oral squamous cell carcinoma (OSCC), a prevalent form of oral cancer, especially in cases with CXCR4/stromal cell-derived factor 1 expression, linking it to recurrence and lymph node metastasis [14,15]. This evidence concerns the gene CXCR4 and oral cavity squamous cell carcinoma.