CEACAM5 and metastatic malignant neoplasm in the lymph nodes: Briefly, the application of multiple clinicopathological parameters (e.g., lymph node metastasis, vascular invasion), laboratory markers (e.g., CEA, CA-199, and CA-72-4), CTCs and CTC subtypes could be synthesized into a valuable prognostic risk model for predicting CRC recurrence and provide more information to physicians and patients to choose more appropriate, individualized surveillance strategies and possibly more aggressive medical treatment.