Positive NGS results involved most frequently the EWSR1 gene in Ewing sarcoma/PNET (n = 5), the FUS gene in myxoid LPS (n = 4), followed by COL1A1 (dermatofibrosarcoma protuberans), STAT6 (solitary fibrous tumor), NTRK3 (NTRK-rearranged sarcoma), NR4A3 (extraskeletal myxoid chondrosarcoma), and the USP6 gene (nodular fasciitis), with one case each of these genes. The gene discussed is EWSR1; the disease is nodular fasciitis.