Point mutations in FGFR3 (S249C), predicted to result in apolipoprotein B mRNA-editing catalytic polypeptide-like (APOBEC) activity [28] as an initial event, are the most common genetic alterations associated with low tumor grades and stages in NMIBC [16,29,30,31,32]. The gene discussed is FGFR3; the disease is neoplasm.