Examples include the co-expression of R- and E-cadherin that suppresses the progression and metastasis in salivary adenoid cystic carcinomas [49], the combined expression of cadherin-6 and cadherin-11 associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma [50], and the co-expression of E- and P-cadherin which is associated with poor prognosis in breast cancer [23]. The gene discussed is CDH3; the disease is metastatic malignant neoplasm in the lymph nodes.