CDH2 and central nervous system cancer: For instance, N-cadherin expression has been associated with both a protective role, with a decrease in tumor migration, invasiveness and dissemination [27,37,38,39], and with a detrimental role, with a documented association between increased N-cadherin expression and high pathological glioma grade [40,41], the presence of radioresistant glioma stem cells [42], and a significant decrease in patient survival [28,41].