Our main findings were the following: (1) N-cadherin is the most frequent cadherin expressed in GBM, present in over 80% of the cases, followed by E-cadherin in about a third of the tumors and P-cadherin in 20%; (2) expression of epithelial cadherins (E- and P-cadherin) determines a distinct imaging and neuropathological profile in GBM; and (3) expression of epithelial cadherins has a significant detrimental impact on GBM patient’s prognosis. Here, CDH2 is linked to glioblastoma.