CDH2 and neoplasm: Importantly, when N-cadherin expression is combined with E- or P-cadherin, divergent tumor subtypes are observed: E- and N-cadherin co-expressing tumors are frequently located in the temporal lobe, with cortical involvement and cysts, and frequently exhibit an epithelial component, while GBMs positive for P- and N-cadherin frequently display a mesenchymal component, with frequent immune infiltrates.