When expressed on T-cells, TIM-3 is an indicator of T cell exhaustion in both chronic viral infections and malignancy [76,77], and its overexpression on tumour cells has been described in several solid tumours, including lung, gastric, colon, hepatocellular and urological malignancies [78], with increased levels correlating with poor survival [78,79]. The gene discussed is HAVCR2; the disease is neoplasm.