SQSTM1 and cancer: In cancer cells, the underlying regulatory mechanisms that result in the metabolic reprogramming of the cell include (among others) the up-regulation of the mutated tumor suppressor p53, Myc (Myelocytomatosis oncogene), HIF1 (hypoxia-induced factor 1), NRF2 (nuclear factor erythroid 2-related factor 2) and SQSTM1 (Sequestosome 1) [39,127,128,129,130,131,132,133].