In turn, this means that the lactate sensing by the breast cancer cells causes an increased expression of lactate transporters and glycolysis enzymes (of these, LDH-A and MCT-4 are those isoenzymes with the highest KM in their respective spectrum of isoenzymes), thereby supporting cancer cell growth irrespective of the acidification of the environment by lactate. The gene discussed is LDHA; the disease is breast cancer.