There was a significant increase in the expression of miRNA-54265 in serum samples from patients with CRC, which specifically binds to the PIWIL2 (Piwi Like RNA-Mediated Gene Silencing 2) protein, forming a PIWIL2/STAT3/phosphorylated SRC complex that promotes proliferation and metastasis by phosphorylating STAT3 [170]. The gene discussed is STAT3; the disease is colorectal carcinoma.