[68Ga]Ga-Pentixafor has been identified as a molecular probe for non-invasive measurement of CXCR4 expression in tumors, and the limited available literature so far has shown low-grade [68Ga]Ga-Pentixafor uptake in HNSCC [11,12,13]. This evidence concerns the gene CXCR4 and head and neck squamous cell carcinoma.