Patients with severe AKI showed considerably higher baseline levels of [TIMP-2] × [IGFBP-7] than those without AKI [1.57 (0.80–6.62) vs. 0.17 (0.05–0.59) (ng/mL)2/1000, p < 0.001]. This evidence concerns the gene IGFBP7 and acute kidney injury.