TP53 and cancer: For example, it has been shown in mice an involvement of p53 during nucleolar stress [78]; in man, several kinds of cancer mutated of retinoblastoma protein (RB) and p53 show the upregulation of rRNA synthesis coupled with a more aggressive phenotype compared with similar tumors not mutated in those genes [79] and also c-Myc is a recognized player in this scenario [80].