Considering that deregulation of glucose metabolism is one of the tumor hallmarks [255] and that PPP1R3C is implicated in several cancers [256,257,258], understanding the mechanisms that regulate the PPP1R3C protein in RCC could be useful to better understand tumor progression and hypothesize potential therapies, using, i.e., miR-4461 as a possible PPP1R3R regulator. The gene discussed is PPP1R3C; the disease is renal cell carcinoma.