Functional analysis of COPB2 conducted in HCT116 and SW480 cells treated with COPB2 siRNA or miR-4461 mimics also showed that the KD of COPB2 inhibits the proliferation, migration, and invasion abilities of CRC cells, suggesting that COPB2 behaves as an oncogene in this tumor. The gene discussed is COPB2; the disease is neoplasm.