Independently on SLAMF1, T. cruzi induces different responses in macrophages to deal with the infection and kill the parasite, such as the type I and II IFN responses, NLRP3 inflammasome activation, IL-18 production, TLR7 and TLR9 activation specifically in the Y strain infection, and IL-11 signaling specifically in the VFRA strain infection. This evidence concerns the gene NLRP3 and infection.