Transcriptomic profiling, in-silico deconvolution and functional network analysis were conducted on RV biopsies, identifying an increase in the mitochondrial dysfunction genes <i>RPPH1</i> and <i>RMPR</i> (padj = 4.67 × 10<sup>-132</sup>, 2.23 × 10<sup>-107</sup>), the cytotoxic T-cell markers <i>CD8a</i>, <i>LAGE3</i> and <i>CD49a</i> (<i>p</i> = 0.0006, <i>p</i> < 0.0001, and <i>p</i> = 0.0118) and proinflammatory <i>caspase-1</i> (<i>p</i> = 0.0055) in CHD. Here, CASP1 is linked to coronary artery disorder.