BCL2 and cancer: Cancer cells employ various mechanisms to suppress apoptosis, including upregulation of anti-apoptotic proteins like B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xL), and Myeloid leukemia 1 (Mcl-1), and downregulation of pro-apoptotic proteins such as Bax and Bim [21].