CRC inhibition of CUR also involves multiple molecular targets including cyclooxygenase-2 (COX-2), transcription factors (NF-kB, beta-catenin), Bcl-2 family members, death receptors (DR5, Fas), caspase proteins, and reactive oxygen species (ROS) [49,50]. This evidence concerns the gene NFKB1 and colorectal carcinoma.