Interestingly, some of the genes impaired by the interaction of NPC, lamin B1, and p53 are also the genes commonly affected by copy number amplifications during cancer progression.These amplified genes, including the famous c-Myc, play critical roles in regulating the cell cycle, maintaining pluripotency, and coordinating cellular responses to many environmental cues in PDAC [81]. Here, NPC1 is linked to cancer.