In neuroblastoma, 1-carbaldehyde-3,4-dimethoxyxanthone (LEM2) prevents mutant p53’s inhibition of TAp73α, a tumor-suppressive C-terminal splice variant, by disrupting both mutant p53 and MDM2 binding to p73, thereby enhancing p73 function [31,144]. The gene discussed is TP53; the disease is neuroblastoma.