TARDBP and dementia: FTLD, a clinically heterogeneous neurodegenerative disorder, represents one of the most common causes of early onset dementia, with symptoms often occurring between 45 and 65 years old [4], and is characterized by the accumulation of different proteins, such as microtubule-associated protein tau (MAPT), ubiquitin, TAR DNA-binding protein 43 (TDP-43), and fused in sarcoma (FUS) [5].