C9orf72 and Alzheimer disease: A total of n = 380 subjects, comprising n = 150 sporadic AD, n = 150 sporadic FTLD, n = 40 GRN mutation carriers (n = 28 genetic FTLD and n = 12 pre-symptomatic subjects), and n = 40 C9orf72 intermediate/pathological expansion carriers (n = 38 genetic FTLD and n = 2 pre-symptomatic subjects), were screened for the presence of variants in the coding regions of 50 candidate genes belonging to the immune system and inflammation (Table 1).