Moreover, the combination of calsyntenin-1 with other synaptic proteins has shown a potential ability to discriminate FTLD subtypes from other type of dementias, such as FTLD TDP-43-subtype from AD and healthy subjects, and GRN/C9orf72 pre-symptomatic mutation carriers from mutation non-carriers [61,62]. This evidence concerns the gene TARDBP and Alzheimer disease.