IGF1 and neoplasm: In human PDAC patient tumor samples, GHR RNA expression is positively and significantly correlated with that of several markers of GH downstream signaling, including IGF1, STAT5B, SOCS2, and JAK2 (Pearson’s correlation coefficients = 0.84, 0.74, 0.73, and 0.49, respectively, false discovery rate (FDR) < 0.05; Figure S7).