Relevance of targeting GHR in pancreatic cancer: GHR is expressed in all pancreatic cell types, albeit variably, with the highest level (92% of cells, mean expression = 4.4) in pancreatic beta cells and the lowest level (11% of cells, mean expression = 0.5) in pancreatic ductal cells of the normal pancreas (Figure S1). Here, GHR is linked to familial pancreatic carcinoma.