AKT1 and neoplasm: In xenograft tumors, querying GH downstream intracellular signaling intermediates predicted from PDAC patient tumor analysis (Figures S7 and S8) show that GHRA-treated groups have significant and consistent reductions in the phosphorylation states of STAT5, STAT3, as well as SRC and AKT in both male (Figure 2E,F) and female mice (Figure 2G).