Moreover, pancreatic cancer cells in culture show a >2-fold increase in the rate of drug efflux and a reduction in the amount of intracellular drug surrogate and ABC transporter substrate [DiOC(2)3] retention following GH treatment, whereas both GHRAs completely suppress the same and show increased retention of the fluorescent compound (Figure 3C and Figure S15). Here, ABCG2 is linked to familial pancreatic carcinoma.