Given that GH action drives the overexpression of multiple ABC transporters in melanoma, liver cancer, and breast cancer [10], and our observed GHR-associated enrichment of the ABC transporter pathway in PDAC patient samples (Figure S8), here we tested and observed a strong positive correlation between RNA expression of GHR and 15 ABC multidrug transporters in PDAC patients (FDR < 0.05, TCGA) (Figure 3A). Here, GH1 is linked to breast cancer.