In xenograft tumors, querying GH downstream intracellular signaling intermediates predicted from PDAC patient tumor analysis (Figures S7 and S8) show that GHRA-treated groups have significant and consistent reductions in the phosphorylation states of STAT5, STAT3, as well as SRC and AKT in both male (Figure 2E,F) and female mice (Figure 2G). This evidence concerns the gene STAT5B and neoplasm.