On the other hand, it is also of pronounced importance that various chalcone-containing scaffolds feature marked potency even in overcoming drug resistance, as they were found to exhibit in vitro and in vivo effects on both drug-susceptible and drug-resistant cancers by targeting the aromatase enzyme (CIP19A1), breast cancer resistance protein (BCRP), vascular endothelial growth factor (VEGF), and ATP binding cassette subfamily G member 2 (ABCG2) [47,48]. Here, VEGFA is linked to cancer.