Indeed, there is a possibility that such a substance in the CP of those with severe PE or hypertension could remarkably affect the neonatal endothelium, because we found a positive association of the CP-induced AT1R mRNA level with the induced VCAM1 mRNA level (Pearson’s correlation r = 0.55, p = 0.028). The gene discussed is AGTR1; the disease is hypertensive disorder.