Real-time qPCR data indicated that the fraction under analysis might induce PCD in human melanoma cells (A2058), through a crosstalk between the extrinsic pathway, mediated by TNF receptors and the catalytic activity of caspase 8, and the mitochondria, via activating pro-apoptotic BCL-2 proteins and CASP9. The gene discussed is BCL2; the disease is melanoma.