According to the proposed model, except for the general players, RhAG and eAE1, carbonic anhydrase II (CAII), the activity of which was shown to be tightly connected to the eAE1 function [7,73,98,99], might also be considered as a target, as there are several reports on CAII inhibitor (acetazolamide, topiramate, etc.,)-associated hyperammonemia [100,101,102,103] and reduced function [104]. Here, CA2 is linked to Hyperammonemia.