These include highly calcium permeable postsynaptic nicotinic acetylcholine receptors, acetylcholine binding and downstream events, serotonin neurotransmitter release cycle, CREB1 phosphorylation through the activation of adenylate cyclase and voltage gated potassium channels. This highlights a specific brain immune response to asthma, indicating that asthma may not only be a respiratory condition but also one that involves complex neuro-immune interactions, as shown in Figure 3. This evidence concerns the gene CREB1 and asthma.