Furthermore, genes related to the inflammatory response such as Ccrl2, Cxcl5, Tnfsf9, Tnfrsf1b, Tnfrsf9, Il6, Ccl7, and Ccr7, and genes involved in integrin cell surface interactions including Itga10, Pecam1, Itgad, Itgb3, Itga3, Itgb7, Itgb2, Icam1, Itga5, and Icam2 were downregulated upon MMP-3 KO in female stroke brains (Figure 4E,F). This evidence concerns the gene ITGA5 and stroke disorder.