Genes related to inflammation such as Ccl5, Cxcl5, Il1a, Tnfsf10, Nfkb1, Tnfrsf1b, Ccr7, Tnfrsf9, Ccl7, Il1b, Il6, and Ccl24 were also downregulated upon MMP-3 KO in male stroke brains (Figure 2E). This evidence concerns the gene MMP3 and stroke disorder.