Similarly, genes involved in integrin cell surface interactions including Itga10, Itgb3, Vcam1, Itgb1, Itgae, Itgb7, Itga1, Itga5, Icam1, Itgb2, Pecam1, and Icam2 were depleted in male MMP-3 KO stroke brains (Figure 2F). This evidence concerns the gene ITGB3 and stroke disorder.