Key genes downregulated in male MMP-3 KO stroke brains included Itga10, Itgb3, Vwf, Col9a2, Col13a1, Vcam1, Itgb1, Itgae, Itgb7, Col1a1, Col4a2, Col9a3, Col4a6, Col1a2, Itga1, Col8a1, Col6a5, Itga5, Col4a1, Col3a1, Icam1, Itgb2, Col2a1, Col7a1, Col5a2, Pecam1, Col6a3, Col18a1, Tnc, Icam2, and Col8a2 (Figure 2F and Figure A2D). The gene discussed is PECAM1; the disease is Stroke.