Key inflammation-associated genes downregulated upon MMP-3 KO in female stroke brains included Tnfsf9, Il6, Tnfrsf9, Tnfrsf1b, Ccrl2, Cxcl5, Ccl7, Ccr7, Fos, Tnf, Jun, Tnfrsf1a, Icam2, Pecam1, Il1rn, Il4ra, Mmp9, Cxcl1, Ccr1, and Ccl11 (Figure 4E, Figure 5A–C and Figure A3C). Here, IL6 is linked to stroke disorder.