Key inflammation-associated genes downregulated upon MMP-3 KO in male stroke brains included Ccr1, Cxcl1, Ccl11, Cxcl2, Ccl6, Il4ra, Irf1, Il15ra, Ccl5, Il10ra, Itgb3, Cxcl5, Il1a, Tlr, Tnfsf10, Nfkb1, Csf1, Adgre1, Tnfrsf1b, Ccr7, Mmp14, Mmp9, Nlrp3, Itga5, Tnfrsf9, Cd40, Il1r1, Ccl7, Sell, Icam1, Icam2, Lif, Il1b, Il6, Ccl24, Pecam1, and Ceacam1 (Figure 2E, Figure 3A–C and Figure A2C). Here, IL1R1 is linked to Stroke.