Representative apoptotic genes that were downregulated in female MMP-3 KO stroke brains included Bax, Casp4, Casp9, Bik, Casp7, Casp6, Bcl10, Bmf, Tnf, Tnfrsf1a, and Tnfrsf1b (Figure 4D, Figure 5B and Figure A3B). This evidence concerns the gene BCL10 and stroke disorder.