MMP3 and Stroke: Our IPA results revealed that female MMP-3 KO stroke brains had negative enrichment scores for inflammation-associated cellular pathways such as leukocyte migration (z = −3.331), inflammatory response (z = −4.186), macrophage classical activation signaling pathway (z = −3.212), and acute phase response signaling (z = −1.474) (Figure 5A,B).