In female MMP-3 KO stroke mice, the mean infarct volume was 11.55 ± 1.62% (**** p < 0.0001 vs. sham), which was significantly smaller than in the female WT MCAO/R group (##p < 0.01 vs. MCAO/R WT) (Figure 1B). The gene discussed is MMP3; the disease is Stroke.