GRN and systemic sclerosis: The sICAM-1 and sVCAM-1 levels were significantly higher in the SSc group (186 vs. 230 ng/L, p < 0.01; 586 vs. 656 ng/mL, p < 0.05), while the serum progranulin (PGRN) levels were observed to be comparable (36 vs. 37 ng/mL, n.s.).