Our aim was to investigate circulating PGRN, sICAM-1, sVCAM-1, CRP levels, and their possible correlations with ECG parameters including QT interval, QT dispersion (QTd), T wave peak-to-end interval (Tpe), and arrhythmogeneity index (AIX-Tpe/QT interval ratio) in patients with SSc. The gene discussed is GRN; the disease is systemic sclerosis.